Analysis of the function of FNDC3B during mammalian development

INTRODUCTION The placenta provides nutrients and oxygen to the developing fetus and facilitates removal of fetal waste. Abnormal placental development and function can have serious consequences for the fetus that include spontaneous abortion, pre-eclampsia, premature birth, , and low birth-weight. One in thirteen babies born in the U.S. each year has low birth-weight (March of Dimes, 2005). Moreover, low birth weight infants can experience serious health problems as newborns, and are at an increased risk of long-term disabilities. Thus, understanding the mechanisms responsible for abnormal placental development is an important step towards the eventual goal of being able to diagnose and ameliorate such conditions.